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KMID : 1134820110400050704
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Journal of the Korean Society of Food Science and Nutrition
2011 Volume.40 No. 5 p.704 ~ p.711
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90-day Repeated-dose Oral Toxity Study of 20 kGy Irradiated Cold Water Extract Powder of Mistletoe
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Kim Jin-Kyung
Jeon Young-Eun
Yin Xing-Fu
Lee Ju-Woon
Kang Il-Jun
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Abstract
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Traditionally, mistletoes have been used as immunostimulant for the management of certain diseases such as cancer with high profile immune depleting potentials. In order to examine the safety of the 20 kGy irradiated cold water extract powder of mistletoes, we performed a 90-day repeated-dose toxicity study with ICR mice. The mice were treated with daily doses of the 20 kGy irradiated cold water extract powder of mistletoes by gavage at 0, 20, 100, and 500 ㎎/㎏/day for 90 consecutive days. We recorded clinical signs of toxicity, body weight, organ weights, histological changes in target organs, hematology, and clinical blood chemistry analysis data for all mice. There were no significant changes in body and organ weights during the experimental period. The hematological analysis and clinical blood chemistry data revealed no toxic effects from the 20 kGy irradiated cold water extract powder of mistletoes. Pathologically, neither gross abnormalities nor histopathological changes were observed between the control and treated mice of both sexes. Collectively, these data suggest that the 20 kGy irradiated cold water extract powder of mistletoes have a high margin of safety.
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KEYWORD
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mistletoes, gamma irradiation, 90-day repeated-dose oral toxity
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